$64 Car Rental Southeast Missouri, MO

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Top Car Deals in Southeast Missouri

* Price found within the past 6 days. Click for updated prices.

Compact SUV

Chevrolet Trax
  • 5 people
  • Unlimited mileage
St Louis, Missouri, USA
Chevrolet Trax

$64

includes taxes & fees
$49 per day
found 1 hour ago
Compact SUV Chevrolet Trax

Standard SUV

Chevrolet Blazer
  • 5 people
  • Unlimited mileage
St Louis, Missouri, USA
Chevrolet Blazer

$65

includes taxes & fees
$50 per day
found 4 hours ago
Standard SUV Chevrolet Blazer

Midsize SUV

Nissan Rogue
  • 5 people
  • Unlimited mileage
St Louis, Missouri, USA
Nissan Rogue

$67

includes taxes & fees
$52 per day
found 4 hours ago
Midsize SUV Nissan Rogue

Fullsize Recreational Vehicle

Nissan Pathfinder
  • 7 people
  • Unlimited mileage
St Louis, Missouri, USA
Nissan Pathfinder

$71

includes taxes & fees
$55 per day
found 4 hours ago
Fullsize Recreational Vehicle Nissan Pathfinder

Economy Special

Managers Special
  • 4 people
  • Unlimited mileage
St Louis, Missouri, USA
Managers Special

$77

includes taxes & fees
$59 per day
found 4 hours ago
Economy Special Managers Special

Special

Managers Special
  • 4 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Managers Special

$78

includes taxes & fees
$60 per day
found 5 hours ago
Special Managers Special

Mini Van

Chrysler Pacifica
  • 7 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Chrysler Pacifica

$84

includes taxes & fees
$65 per day
found 1 hour ago
Mini Van Chrysler Pacifica

Midsize Elite

Tesla Short Range Model 3
  • 5 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Tesla Short Range Model 3

$103

includes taxes & fees
$80 per day
found 1 hour ago
Midsize Elite Tesla Short Range Model 3

Premium Crossover

Dodge Durango
  • 7 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Dodge Durango

$104

includes taxes & fees
$81 per day
found 1 hour ago
Premium Crossover Dodge Durango

Standard Elite SUV

Ford Explorer
  • 7 people
  • Unlimited mileage
Saint Louis, Missouri, USA
Ford Explorer

$109

includes taxes & fees
$85 per day
found 1 hour ago
Standard Elite SUV Ford Explorer

Luxury SUV

Jeep Grand Wagoneer
  • 7 people
  • Unlimited mileage
St Louis, Missouri, USA
Jeep Grand Wagoneer

$122

includes taxes & fees
$95 per day
found 1 hour ago
Luxury SUV Jeep Grand Wagoneer

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What you need to know for your Southeast Missouri car rental

Reasons to book a car rental in and around Southeast Missouri

Renting a car in Southeast Missouri offers you the freedom and flexibility to explore the region at your own pace. Whether you’re seeking outdoor adventures or simply want to take in the scenic beauty, having a rental car makes it convenient to visit key attractions. For example, you can easily reach Sam A. Baker State Park, located 8 miles away, perfect for hiking and enjoying nature. The K Bridge Recreation Area, 17 miles from Southeast Missouri, is ideal for family outings and outdoor fun, while the Millstream Gardens Conservation Area, just 15 miles away, provides a peaceful retreat.

A rental car also allows you to discover nearby cities like Central Fredericktown, 10 miles away, where you can explore local landmarks such as the Madison County Courthouse. Des Arc, located 11 miles from Southeast Missouri, offers Clearwater Lake and more outdoor experiences. If you're visiting Annapolis, 14 miles away, you can easily access the Taum Sauk Nature Museum and other attractions. With a rental car, you can manage your luggage and travel plans with ease, making it an ideal choice for all types of travelers.

Where to stay around Southeast Missouri

  • Central Fredericktown: Located 10 miles from Southeast Missouri, Central Fredericktown offers a blend of outdoor and city-themed experiences. Travelers can enjoy activities at the local recreational area and golf course. Key attractions include the historic Madison County Courthouse and the scenic Millstream Gardens Conservation Area. For family-friendly outings, visit Sam A. Baker State Park, which is perfect for adventure seekers. With various restaurants nearby, Central Fredericktown is a convenient and enjoyable place to stay.
  • Annapolis: Situated 14 miles away from Southeast Missouri, Annapolis is ideal for those seeking outdoor adventures and beautiful scenery. The K Bridge Recreation Area is a great urban park for family outings, while the renowned Sam A. Baker State Park offers stunning landscapes for adventurers. For a cultural experience, visit the Taum Sauk Nature Museum. Additionally, Annapolis features local wineries and distilleries, making it a delightful spot for food and drink enthusiasts.
  • Des Arc: Located 11 miles from Southeast Missouri, Des Arc is a haven for outdoor lovers and adventure seekers. Visitors can explore the picturesque Clearwater Lake, perfect for romantic outings or peaceful days by the beach. The K Bridge Recreation Area provides a family-friendly environment, while the nearby Sam A. Baker State Park caters to those looking for outdoor activities. Des Arc also boasts local wineries, offering a taste of the region's best beverages.

10 tips to save on your car rental in and around Southeast Missouri

  1. Use filters to find the right car: Refine your search according to vehicle type and features. Whether you’re looking for an SUV for extra space, a convertible for summer joyrides, or an economy car for budget-friendly travel, utilize the filters on Expedia to discover the perfect option for your trip.
  2. Book in advance to help lower costs: Rental rates can vary significantly based on demand, so it’s advisable to reserve your vehicle well in advance of your trip. Booking early often allows you to secure lower prices and better availability, particularly during peak travel seasons.
  3. Consider a smaller car for savings: Compact cars are typically more affordable to rent and easier to maneuver in crowded areas. Mid-size vehicles strike a good balance between cost, comfort, and fuel efficiency.
  4. Age guidelines: Drivers under 30 may encounter higher deposits or daily fees, and certain vehicle categories—such as SUVs or luxury models—might not be accessible. This can also apply to renters over the age of 70. Always verify the age requirements prior to making your reservation.
  5. Check fuel policies: Some rental agreements require you to follow a full-to-full fuel policy, meaning you must return the vehicle with a full tank to avoid additional charges. This is generally the most favorable option. Other policies may include full-to-empty or prepaid fueling alternatives, which are also acceptable. Just ensure you return the car empty in those cases.
  6. Save on city and airport pickups: Picking up your rental car at the airport often incurs a surcharge, but the convenience might justify the extra cost.
  7. Know your payment options: Many car rental companies primarily accept credit cards for payment.
  8. Understand your insurance coverage: Car rental insurance can help you avoid unforeseen expenses and provides peace of mind should something unexpected occur during your trip. It’s easy to add rental insurance when booking through Expedia.
  9. Consider unlimited mileage: If you’re planning extensive road trips, seek out rentals that offer unlimited mileage to prevent additional fees.
  10. Bring your driver's license and ID: A valid driver’s license is essential for renting a car.

Finding the cheapest car rentals in Southeast Missouri

Using our Search Wizard

If the deals that are available on our page do not suit your needs, then enter Southeast Missouri into the search wizard at the top of the page. We will compare all the best deals available for your car rental in Southeast Missouri and provide you with a list of the cheapest options, with no added fees.

Renting a car in Southeast Missouri

Pay at pickup is available, so you don’t have to worry about spending your money until you arrive at your vehicle in Southeast Missouri. We partner with reliable partners that guarantee an enjoyable experience for solo travelers, couples, and families. Package your car with a flight or hotel to unlock even more savings from Expedia.

Expected prices in Southeast Missouri

Prices are subject to seasonal change depending on when you decide to arrange your car rental but right now you can book from $64.

Flexibility & Cancellation

Most car suppliers offer penalty-free cancellations, so you don’t have to worry about losing money if your plans change. To cancel your booking log into your account through the Trips portal. Click manage booking and cancel this car. If you needed to alter your booking, then you can create a new one once you have canceled.

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Car classes available from Expedia in 2026

The classes of vehicles available will change depending on your chosen location.

Car Rental Information

Popular car types
SUV, Full Size, Economy
Car suppliers available
Our best deal of the day
$64
Our second best deal of the day
$65
Our third best deal of the day
$67
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Frequently asked questions

What happens if I need to cancel my Southeast Missouri car reservation?
We have good news! You should be given a complete refund if you notify us more than six hours ahead of picking up the car. Your itinerary contains details about this, and so does our Customer Service Portal. Not all prepaid bookings qualify for a refund though, so it's a good idea to read through your cancellation policy.
How do I find the best car rental deals in Southeast Missouri with Expedia?
Whatever sort of ride you're after, Expedia will help you track down the best deal. Simply compare offers from well-known rental suppliers and pick the option that's right for you. Love to drive away with even more in your wallet? Combine your Southeast Missouri car rental with flight or hotel bookings.
How old do you have to be to rent a car in Southeast Missouri?
Rental car rules in Southeast Missouri require drivers to be 21 and older. Are you a younger driver? Surcharges and restrictions may apply. Many rental suppliers impose what is known as a young driver surcharge, which is an additional fee to the rental car cost. Restrictions often apply to the categories of cars available to young people too. Age limits may vary between outlets, so check before you book.
What do you need to rent a car in Southeast Missouri?
You'll need to present your driver's license and a credit card at the rental counter. Prior to the pickup date, check with your chosen rental company whether anything else is needed. For example, you may also need to provide proof of insurance.
Can I rent a car for a month or longer in Southeast Missouri?
Whether you plan to stop in Southeast Missouri or discover what's beyond, it's easy to reserve a long-term rental with Expedia. Enter your trip dates and pick-up/drop-off locations and we'll find you excellent long-term car rental deals.
Where can I find a Southeast Missouri car rental if I am younger than 25?
Some Southeast Missouri outlets will rent cars to drivers under 25, and others won't. Age policies differ between suppliers, so you'll want to do some research. Also, find out if there are extra costs. Some outlets will have a surcharge for customers between 21 and 24. Be sure to read through the terms and conditions so you know what to expect.
What insurance should I choose for my car rental in Southeast Missouri?
It's a wise idea to have collision protection to cover your Southeast Missouri car rental against theft, accident damage and vandalism. And with Expedia, you can easily purchase this insurance for your vehicle at the time of booking. Covering primary physical damage of up to $35,000, it also offers 24-hour emergency help and no deductible should you need to make a claim. Plans changed? If you cancel your policy before your scheduled collection time, you'll get all your money back.
What are the cheapest car rentals in Southeast Missouri?
You can find cheap car rentals in Southeast Missouri from $17 a day with Enterprise's midsize 2/4 door. Car rentals for exploring Southeast Missouri are picked up at the region's main gateway, Saint Louis International (STL). From there it's an easy drive to towns like Van Buren and Cape Girardeau. Suppliers such as Enterprise, Alamo Rent A Car, and Avis operate across the region. Rates shift by vehicle type and dates, so compare a few pickup points and dates on Expedia to find a rate that suits your trip. For more options, explore Economy Car Rentals in Southeast Missouri.
What are the best car rentals in Southeast Missouri?
Car rentals across Southeast Missouri offer a full range of vehicle types from providers like Enterprise, Alamo Rent A Car, and Avis, broadly available in the region's main cities — Van Buren, Cape Girardeau, and Eminence. The most common car classes include:
  • Midsize 2 or 4 door
  • Fullsize 2 or 4 door
  • Compact SUV
  • Midsize SUV
  • Compact 2 or 4 door
These options cater to various traveler needs, whether you're a solo explorer, a couple, a family, or a small group. Choose based on passenger count, luggage, and whether you're driving in the city or exploring the wider region. For more options, explore Minivan Car Rentals in Southeast Missouri.
What are the best car rental companies in Southeast Missouri?
For car rentals across Southeast Missouri, well-rated providers like Enterprise, Alamo Rent A Car, and Avis offer a strong mix of vehicles and competitive rates, with wide availability in the region's main cities — Van Buren, Cape Girardeau, and Eminence. Compare suppliers and pickup points on Expedia to find a great rate and the right vehicle for your trip.
Can I rent a car from Saint Louis International (STL) for exploring Southeast Missouri?
Yes — you can pick up a rental car right at Saint Louis International (STL) for exploring Southeast Missouri. Providers including Enterprise, Alamo Rent A Car, and Avis operate at the airport, with rates from around $17 a day. STL is the region's main gateway and a convenient base for reaching cities across the area, from Van Buren to Cape Girardeau.
Can I rent a car one-way in Southeast Missouri?
Yes, one-way car rentals work well across Southeast Missouri — pick up in one city, such as Van Buren, and drop-off in another, like Cape Girardeau, which is ideal for regional road trips, with prices starting from around $21 a day. Providers like Enterprise and Alamo Rent A Car offer flexible one-way options. A one-way drop-off fee may apply, so confirm it when booking on Expedia.
Are there electric or hybrid car rental companies in Southeast Missouri?
Electric and hybrid car rentals are available across Southeast Missouri, including in Van Buren and Cape Girardeau. Avis and Budget both offer hybrid options from $17 a day and electric options from $20 a day. EVs keep fuel costs low, and charging is widely available along major routes. Book a few weeks ahead as demand is high, and plan charging stops for longer regional drives.
What are the best luxury car rental companies in Southeast Missouri?
For luxury car rentals across Southeast Missouri, Enterprise offers premium crossover cars from $26 a day, while Alamo Rent A Car offers a premium crossover from $41 a day. Payless also provides luxury elite 2 or 4 door cars from $43 a day. These high-end vehicles offer extra comfort and space for exploring the region in style. You'll find them in the region's main cities like Van Buren and Cape Girardeau. Use Expedia's car-class filters to browse premium options and compare rates before you book. For more options, explore Luxury Car Rentals in Southeast Missouri.
What are the best car rentals in Southeast Missouri for families or groups?
For families or groups exploring Southeast Missouri, SUVs and minivans give you room for passengers, car seats, strollers, and luggage — available across the region's cities, from Van Buren to Cape Girardeau:
  • Budget: midsize SUV from $23 a day — seats up to 5 with room for 3 large suitcases
  • Budget: mini passenger van from $39 a day — seats up to 8 with room for 6 large suitcases
  • Enterprise: fullsize SUV from $40 a day — seats up to 6 with room for 3 large or 5 medium suitcases
These keep everyone comfortable for both city driving and longer trips into the surrounding area. Book a few weeks ahead, as the larger vehicles can have lower availability during busy periods. For more options, explore SUV Car Rentals in Southeast Missouri.
What are the best car rentals in Southeast Missouri for solo travelers?
The best car rentals in Southeast Missouri for solo travelers are economy and compact classes — small, easy to park, and cheap to run for one person exploring the region at their own pace, available across cities like Van Buren and Cape Girardeau:
  • Economy car, from $26 a day — fits up to 5 people and 2 medium suitcases, nimble on tight city streets
  • Compact car, from $19 a day — fits up to 5 people and 3 medium suitcases with a little more room for luggage
Both comfortably fit a solo traveler plus a bag or two. Compare suppliers on Expedia to find the right car for getting around the region. For more options, explore Compact Car Rentals in Southeast Missouri.
What are the best car rentals in Southeast Missouri for couples?
The best car rentals in Southeast Missouri for couples balance comfort and easy handling for two, available across the region's cities like Van Buren and Cape Girardeau:
  • Midsize car, from $17 a day — fits up to 5 people and 3 large suitcases with smooth cruising for two
  • Compact SUV, from $22 a day — fits up to 5 people and 3 medium suitcases with a higher ride for regional day trips
Both give a couple comfortable seating and trunk space without being hard to park. For a special trip, consider a fullsize car, from $20 a day, for scenic drives around Southeast Missouri. For more options, explore Midsize Car Rentals in Southeast Missouri.
What are the closest airports to Southeast Missouri for car rental pick-up?
Several airports offer car rental pick-up for exploring Southeast Missouri, giving you flexible options close to your arrival point:
  • Saint Louis International (STL)
  • Cape Girardeau Regional Airport (CGI)
These airports provide convenient access to the region. Compare rental rates at each airport on Expedia to find a rate that fits your trip.
Which side of the road do you drive on in Southeast Missouri?
In Southeast Missouri, you drive on the right-hand side of the road. This is consistent with driving laws across the United States of America. Keep to local speed limits and traffic laws for a safe, easy drive while exploring the region's cities like Van Buren and Cape Girardeau, and the roads between them. If you're used to driving on the other side, give yourself a little time to adjust — take extra care at intersections and roundabouts, which flow in the opposite direction.
What are the best road trip destinations from Southeast Missouri by rental car?
A rental car in Southeast Missouri unlocks a variety of road trip destinations, with St. Louis offering several iconic landmarks just a short drive away. Having your own vehicle makes it easy to explore these attractions and venture further into the region. Top destinations to consider include:
  • Gateway Arch, St. Louis, Missouri, approximately 2 miles away. This iconic monument offers stunning views and a deep dive into American history, perfect for families and history buffs.
  • St. Louis Union Station, St. Louis, Missouri, approximately 1 mile away. Once a bustling train station, it's now a vibrant entertainment complex with dining and attractions, great for couples or groups.
  • Busch Stadium, St. Louis, Missouri, approximately 2 miles away. For sports enthusiasts, catching a game or taking a tour here is a classic St. Louis experience.
You can also time your trip around exciting events like Soulard Mardi Gras (January-February) or the Festival of Nations (August) in St. Louis. For unique activities, consider adding a St. Louis City Museum General Admission Ticket or a Private Tour of St. Louis's Iconic BBQ Joints & Breweries to your itinerary. Beyond St. Louis, your rental car allows you to discover other charming regional cities like Van Buren, Cape Girardeau, and Eminence, each offering distinct local flavors and outdoor adventures. For more options, explore Fullsize Car Rentals in Southeast Missouri.
Are there any hidden fees when renting a car on Expedia?
Expedia aims to show the key price and important rental details clearly during booking, so you know what to expect before you reserve. In some cases, car rental companies may apply additional charges at pick-up or during the rental, such as security deposits, tolls, fuel charges, extra driver fees, or local requirements, so it's worth checking the supplier's rental terms before you book.
Are there any long-term car rentals in Southeast Missouri?
Yes, there are several long-term car rental options available in Southeast Missouri. Whether you're planning an extended holiday with the family, relocating temporarily, or simply need a vehicle for several weeks or months, many car rental providers offer flexible long-term rental plans tailored to your needs. Click on our long-term car rental deals page, enter your trip information and then book a ride that suits.
Do you need insurance to rent a car in Southeast Missouri?
No, you don't need personal auto insurance to rent a car in most cases. You will, however, be required to purchase some insurance to cover the duration of the rental. Rental companies will offer this insurance when you rent the car. Certain personal car insurance policies can also be applied to rental cars, and travelers can even use non-owner car insurance if they rent cars often but don't have a car of their own. Additionally, some car rentals simply include rental car insurance within the price of the rental.
How much does it cost to rent a car in Southeast Missouri?
Budget car rental in Southeast Missouri can be easy to find, with prices based on rates seen within the past seven days from $64. To find some of the cheapest options, sort your search results by price and use filters to match your budget and travel needs. For added flexibility, it's also worth exploring one-way car rentals.
What are the top car rental deals in Southeast Missouri?
No matter what kind of vehicle you're looking for, Expedia makes it easy to find a great car rental deal in Southeast Missouri. The easiest way to get a good deal on a rental car is to use our filters. At the top of the filter list, you'll find a section featuring our best car rental offers. Check the filter for "Great Deal," and your search results will be filled with specials. Compare offers from trusted rental providers, choose the option that fits your trip, and book with confidence. For even more value, bundle your Southeast Missouri car rental with a hotel or flight to unlock additional savings.
What do I need to rent a car in Southeast Missouri?
To rent a car in Southeast Missouri, a current driver's license and a credit card in the same name are essential. If you're opting out of the company's insurance plan, then you may also need proof of other coverage. Rules may differ between rental companies, so read through your policy.
What happens if I need to cancel my Southeast Missouri car rental?
If you need to cancel your Southeast Missouri car rental, read over the policy to be sure, but almost all prepaid rentals are eligible for a complete refund if you notify us at least six hours prior to the pickup time, though there may be some exclusions so check your itinerary for more information, or just click through to our Customer Service Portal.

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